Avinash Kale



  • Ph.D. in Protein crystallography, Rijksuniversite it Groningen, Groningen, the Netherlands. (Dec 2002-2007).
  • Masters in Physical chemistry, Indian Institute of Technology, Bombay, India (March 2001).
  • Bachelors in Chemistry Honors, Holkar Science College, Indore, India (March 1998).


  • Reader -F Centre for Excellence in Basic Sciences, Mumbai, India (May 2017 onwards)
  • Visiting Assistant Professor- Centre for Excellence in Basic Sciences, Mumbai, India (May 2016 - Apr 2017)
  • Visiting Scientist-II - Centre for Excellence in Basic Sciences, Mumbai, India (Apr 2013 - Apr 2016)
  • Research Associate (RA-3) -Center for Excellence in Basic Sciences, Mumbai, India (Jan 2013 - Mar 2013)
  • Visiting Scientist -Bhabha Atomic Research Center, Trombay, Mumbai, India. (Nov 2011- Dec 2012)
  • Post-doc Scientist - University of Oulu, Oulu, Finland. (Apr 2011-Sep 2011)
  • Post-doc Research Associate (PDRA) - University of Sheffie ld, Sheffie ld, United Kingdom. (Jan 2008- Dec 2010)
  • Project Assistant - Center for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India. (May 2001-Oct 2002)

Research areas:

  • Actin regulation; Mosquito Borne Diseases; ageing in peroxisomes; searching cure for depression; and structural insights of resolvases.
  • My broad area of research includes Actin regulation, and Mosquito Borne Diseases.

Selected Publications

  • Pathak S., Gupta R., Parkar H., Joshi N., Nagotu S., Kale A. The role of Colchicine on actin polymerization dynamics; as a potent anti-angiogenesis factor. (July 2021) Journal of Biomolecular Structure and Dynamics DOI: 10.1080/07391102.2021.1965911
  • Pathak S.,  Parkar H., Tripathi S., Kale A. Ofloxacin as a disruptor of actin aggresome "Hirano bodies": A potential repurposed drug for the treatment of neurodegenerative diseases (October 2020) Frontiers Aging Neuroscience DOI: 10.3389/fnagi.2020.591579
  • Colvin D, Dhuri V, Verma H, Lokhande R, Kale A Proteomic and metabolomic approach to rationalize the differential mosquito larvicidal toxicity in Bacillus sp. isolated from the mid-gut of Culex quinquefasciatus mosquito larvae (September 2020) Analytical Science Advances DOI: 10.1002/ansa.202000081
  • Pathak S.,  Deori N., Sharma A., Nagotu S., Kale A. In vitro, in vivo and in silico rationale for the muscle loss due to therapeutic drugs used in the treatment of Mycobacterium tuberculosis infection (August 2020) Journal of Biomolecular Structure and Dynamics DOI: 10.1080/07391102.2020.1806928
  • Colvin D, Dhuri V, Verma H, Lokhande R, Kale A Enterococcus durans with mosquito larvicidal toxicity against Culex quinquefasciatus, elucidated using a Proteomic and Metabolomic approach (March 2020) Scientific Reports DOI: 10.1038/s41598-020-61245-2
  • Pathak S., Tripathi S., Deori N., Ahmad B., Verma H., Lokhande R., Nagotu S., Kale A. Effect of Tetracycline family of antibiotics on actin aggregation, resulting in the formation of Hirano bodies responsible for neuropathological disorders (January 2020) Journal of Biomolecular Structure and Dynamics DOI: 10.1080/07391102.2020.1717629
  • Dalal K., Khorate P., Dalal B., Chavan R., Bhatia S., Shukla A., Kale A., Shankarkumar A. Differentially expressed serum host proteins in hepatitis B and C viral infections (December 2018) Virus Disease DOI: 10.1007/s13337-018-0484-y
  • Deori N.M., Kale A., Maurya P.K., Nagotu S. Peroxisomes: Role in Cellular Ageing and Age-Related Disorders (October 2018) Biogerontology DOI: 10.1007/s10522-018-9761-9
  • Punjabi K., Mehta S., Yedurkar S., Jain R., Mukherjee S., Kale A.` and Deshpande S. Extracellular synthesis of silver nanoparticle by Pseudomonas hibiscicola – Mechanistic approach (March 2018) Advances in Nano Research DOI: https://doi.org/10.12989/anr.2018.6.1.081
  • Chavan R.; Bapat S. Patil V.; Colvin D.; Kale A. Computational analysis of Influenza proteins with ayurvedic medicines (July 2017) Receptors & Clinical Investigation DOI: 10.14800/rci.1574.
  • Khavnekar, S.; Dantu, S.C.; Sedelnikova, S.; Ayora, S.; Rafferty, J.; and Kale, A. “Structural insights into dynamics of RecU-HJ complex formation elucidates key role of NTR and stalk region towards formation of reactive state” Nucleic Acid Research (November 2016); DOI: 10.1093/nar/gkw1165.
  • Chavan, R.; Colvin D.; Dahake, R.; Chowdhary, A.; Mukherjee, S.; Kale, A. “Differential proteomic analysis of respiratory samples from patients suffering from influenza” Virus Disease (July 2016); DOI: 10.1007/s13337-016-0332-x.
  • Dantu, S.C.; Khavnekar, S.; Kale, A. “Conformational dynamics of Peb4 exhibit “mother’s arms” chain model: A molecular dynamics study” Journal of biomolecular Structure & Dynamics (July 2016) DOI: 10.1080/07391102.2016.1209131.
  • Mothi, N.; Muthu, S.A.; Kale, A.; Ahmad, B. “Curcumin promotes fibril formation in F isomer of human serum albumin via amorphous aggregation” Biophysical Chemistry (August 2015) DOI: 10.1016/j.bpc.2015.08.002.
  • Kale, A.; Hire, R., Hadapad, A.; D'souza, S.F.; Kumar, V. “Interaction between mosquito-larvicidal LysinibacillusSphaericus Binary toxin components: analysis of complex formation” Insect Biochemistry and Molecular Biology (November 2013) DOI:10.1016/j.ibmb.2013.07.011.
  • Gupta, G.D.; Kale, A.; Kumar, V. “Molecular evolution of translin superfamily proteins with in the genomes of eubacteria, archaea and eukaryotes” Journal of Molecular Evolution (December 2012) DOI:10.1007/s00239-012-9534-z. (Equal contribution; cover page article; cover page designed by me).
  • Kale, A.;Suwarnchat, C.; Phansopa, C.; Craven, J.; Rafferty, J.B.; Kelly, D.J. “The virulencefactor PEB4 and the periplasmic protein Cj1289 are two structurally related SurA-likechaperones in the human pathogen Campylobacter jejuni” Journal of Biological Chemistry (June 2011) DOI: 10.1074/jbc.M111.220442.
  • Kale, A.;Pijning, T.; Sonke, T.; Dijkstra, B.W.; Thunnissen, A.M.W.H. “Crystal Structure of the Leucine Aminopeptidase from Pseudomonas putida Reveals the Molecular Basis for its Enantio-selectivity and Broad Substrate Specificity” Journal of Molecular Biology (May 2010) DOI: 10.1016/j.jmb.2010.03.042.


Actin Polymerization In Apicomplexan: The Structural, Functional, And The Evolution analysis,

Publisher: Springer-Nature (2019)

Editor: Avinash Kale

Authors: Samridhi Pathak, Ricka Gauba, Sarita Tripathi, Dhriti Sheth, Sarath C. Dantu, Avinash Kale

Print ISBN: 978-981-13-7449-4         Online ISBN: 978-981-13-7452-4

DOI: https://doi.org/10.1007/978-981-13-7450-

Chapter Number Details

Samridhi Pathak; Tripathi S.; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Actin polymerization: A cellular perspective in motility”. https://doi.org/10.1007/978-981-13-7450-0_1


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Actin: The central ubiquitous player in the phenomenon”. https://doi.org/10.1007/978-981-13-7450-0_2


Samridhi Pathak; Ricka Gauba; Dhriti Sheth, Sarath C. Dantu; Avinash Kale “Formin: The multidomain elongator of polymer”. https://doi.org/10.1007/978-981-13-7450-0_3


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Profilin: The associates of Formin”. https://doi.org/10.1007/978-981-13-7450-0_4


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis”. https://doi.org/10.1007/978-981-13-7450-0_5


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Cyclase associated protein (CAP): The silent worker” https://doi.org/10.1007/978-981-13-7450-0_6


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Capping Protein (CP): The formin competitor” https://doi.org/10.1007/978-981-13-7450-0_7


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Coronin: An Overview” https://doi.org/10.1007/978-981-13-7450-0_8


Samridhi Pathak; Ricka Gauba; Sarath C. Dantu; Avinash Kale “Evolution: The hallmarks of Gliding motility in apicomplexan” https://doi.org/10.1007/978-981-13-7450-0_9


Samridhi Pathak; Ricka Gauba; Avinash Kale “Actin Polymerization in Apicomplexans: A Novel Perspective” https://doi.org/10.1007/978-981-13-7450-0_10


Book Chapter

Chapter title: Nanoparticles as artificial chaperons suppressing protein aggregation: Remedy in neurodegenerative diseases

Book series title: Nanotechnology in the Life Sciences

Publisher: Springer-Nature (2021)

Editor: Hemen Sarma, Sanket Joshi, Ram Prasad, Josef Jampilek

Authors: Samridhi Pathak, Sarita Tripathi, Avinash Kale

Print ISBN 978-3-030-61984-8      Online ISBN 978-3-030-61985-5

DOI: https://doi.org/10.1007/978-3-030-61985-5_12

Book Chapter

Chapter title: Role of the cytoskeletal protein, actin in various disease polymorphisms

Book Title: Dietary Phytochemicals

Book Subtitle title: Dietary Phytochemicals- A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer, and Diabetes

Publisher: Springer-Nature (2021)

Editor: Chukwuebuka Egbuna, Sadia Hassan

Authors: Samridhi Pathak, Avinash Kale, C,M Santosh Kumar, Mansoor Sheikh

Print ISBN 978-3-030-72998-1      Online ISBN 978-3-030-72999-8

DOI: https://doi.org/ 10.1007/978-3-030-72999-8


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