Jacinta S. D’Souza

Professor

Educational Qualifications:

  • M.Sc in Molecular Biology from TIFR
  • PhD in Molecular Biology from TIFR
  • Ex-Scientific Officer (until Jan’09) from TIFR

Positions held, including current

  • Professor (January 2018 -)
  • Associate Professor (January 2016 - 2017)
  • Adjunct Professor, Manipal University (August 2015 -)
  • Reader 'F' (2010-2015)
  • Scientific Officer, TIFR (1998 – 2009)
  • Scientific Asstt., TIFR (1985 – 1998)

Research areas

  • Protein-Protein Interactions, Flagellar Biology, Chlamydomonas stress physiology

List of selected publications

  • Jacinta S. D’Souza*, (2020) The 2020 Pandemic of COVID-19. Spinco Biotech Cutting Edge Volume 9(12): 16-20.
  • Dash, A., Gurdaswani, V., D'Souza, J.S. and Ghag, S.B., (2020) Functional characterization of an inducible bidirectional promoter from Fusarium oxysporum f. sp. cubense. Scientific reports, 10(1), p.2323.
  • Yogesha M, Venkatramanan G. Rao, Praveen Devangad, Jacinta D’Souza and Santhosh Chidangil, (2020) A chemometric study combined with spectroscopy for the quantification of secondary structure of flagellar‐associated protein 174 (FAP174). Journal of Chemometrics; 34(5): e3221. https://doi.org/10.1002/cem.3221.
  • Jacinta S. D’Souza*, Ciliary Dysfunction: from relative obscurity to a formidable position. (2019) Spinco Biotech Cutting Edge (100th Edition) Volume 9(4): 64-65.
  • Sourabh M. Mehta, Shraddha Mehta, Harries Muthurajan and Jacinta S. D’Souza (2019) Facile method for detection of cysteine using a paper-based 2D plasmonic device. Biomedical Microdevices, 21 (3), 55-61.
  • Yogesha M. Ashtkar, Kiran Chawla, Aseefhali Bankapur, Mahendra Acharya, Jacinta S. D’Souza and Santhosh Chidangil (2019) Micro-Raman study of some Urinary Tract Infection causing bacteria. Analytical and Bioanalytical Chemistry, 411 (14), 3165.
  • Marilyn P. Sequeira, Jacinta S. D’Souza, Aditya Dharmadhikari, Jayashree A. Dharmadhikari, Parinda Vasa and Deepak Mathur. (2018) Laser-induced DNA damage is quenched by salts. Applied Physics Letters 113 (11), 113701.
  • Mehta, S.M., Sequeira, M.P., Muthurajana, H. and D’Souza, J.S., (2018) Rapid synthesis of gold and silver nanoparticles using tryptone as a reducing and capping agent. Applied Nanoscience, 8: pp. 759-769.
  • Yogesha, M., Rao, V.G., Martis, E.A., Coutinho, E.C., Gohlke, H., Chidangil, S., Dongre, P.M. and D'Souza, J.S.*, (2017) Structural features of FAP174, a MYCBP-1 orthologue from Chlamydomonas reinhardtii, revealed by computational and experimental analyses. RSC Advances, 7(81), pp.51391-51402.
  • Sequeira, M.P., Sinha, S., Motiwalla, M.J., Rao, V.G. and D'Souza, J.S.*, (2017) Defects in the ratio of the dynein isoform, DHC11 in the long-flagella mutants of Chlamydomonas reinhardtii. Biochemical and biophysical research communications, 482(4), pp.610-614.
  • Dharmadhikari, J.A., Dharmadhikari, A.K., Kasuba, K.C., Bharambe, H., D’Souza, J.S., Rathod, K.D. and Mathur, D., (2016) Optical control of filamentation-induced damage to DNA by intense, ultrashort, near-infrared laser pulses. Scientific Reports, 6, p.27515.
  • Rao V. G., Sarafdar Ruhi, Twinkle Chaudhary, Priyanka Sivadas, Pinfen Yang and D’Souza J. S. (2016) An AKAP240 binding flagellar-associated protein from Chlamydomonas reinhardtii. BMC Cell Biology 17: 24-33
  • J. A. Dharmadhikari, A. K. Dharmadhikari, K. C. Kasuba, H. Bharambe, J. S. D’Souza, K. D. Rathod and D. Mathur, (2016) Optical control of filamentation induced damage to DNA by intense, ultrashort, near-infrared laser pulses. Scientific Reports 6:27515 | DOI: 10.1038/srep27515.
  • Dolly K. Khona, Seema Shirolikar, Deodhar, Erik Hom, D’Souza J. S., (2016) NaCl-induced palmelloidy in the green chlorophyte, Chlamydomonas reinhardtii. Algal Research, 16: 434-448.
  • Sirisha V. L., Mahuya Sinha, Kanak Gawade and Jacinta S. D’Souza, (2016) KCl Induces PCD through a Mitochondrion-mediated Caspase-independent Pathway in Chlamydomonas reinhardtii. Phycologia, 55: 378-392
  • K. C. Kasuba, S. L. Vavilala, J. S. D'Souza (2015) Apoptosis-like cell death in unicellular photosynthetic organisms—A review. Algal Research 12: 126-133
  • S. L. Vavilala, K. K. Gawde, M. Sinha, J. S. D’Souza, (2015) Programmed cell death is induced by hydrogen peroxide but not by excessive ionic stress of sodium chloride in the unicellular green alga Chlamydomonas reinhardtii. European Journal of Phycology 50: 422-438.
  • Aditya K. Dharmadhikari, Harish Bharambe, Jayashree A. Dharmadhikari, Jacinta S. D’Souza and Deepak Mathur, (2014) Ultrafast laser induces both single stranded and double stranded breaks in plasmid DNA. Physics Review Letters 112: 138105.
  • Mustafa J. Motiwalla, Marilyn P. Sequeira and Jacinta S. D’Souza(2014) Two Calcium-Dependent Protein Kinases from Chlamydomonas reinhardtii are transcriptionally regulated by nutrient starvation. Plant Signaling and Behaviour 9: e27969 (10.4161/psb.27969).
  • Sirisha V. L., Mahuya Sinha and Jacinta S. D’Souza(2014) Menadione-induced caspase-dependent programmed cell death in the green alga Chlamydomonas reinhardtii. Journal of Phycology 50: 587–601.
  • Aditya K. Dharmadhikari, Harish Bharambe, Jayashree A. Dharmadhikari, Jacinta S. D’Souza and Deepak Mathur, (2014) Ultrafast laser induces both single stranded and double stranded breaks in plasmid DNA. Physics Review Letters 112: 138105.
  • Elvis A. F. Martis, Rakesh C. Chandarana, Mushtaque S. Shaikh, Premlata K. Ambre, Santosh R. Nandan, Jacinta S. D’Souza, Krishna R. Iyer, Evans C. Coutinho and Raghuvir R. S. Pissurlenkar, (2014) Quantifying Ligand-Receptor Interactions for Gorge Spanning Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 33: 1107-1125.
  • Dolly Khona*, Venkatramanan Rao*, Mustafa J. Motiwalla, Sreekrishna Varma P. C., Anisha Kashyap, Koel Chaudhary, Seema Shirolikar, Lalit Borde, Jayashree A. Dharmadhikari, Aditya K. Dharmadhikari, Siuli Mukhopadhyaya, D. Mathur and Jacinta S. D'Souza. (2013) Anomalies in the motion dynamics of long-flagella mutants of Chlamydomonas reinhardtii. (*Equal contribution) J of Biological Physics 39: 1-14.
  • Dolly K. Khona, Dongre Shounak and Jacinta S. D'Souza, (2013) BolA-like protein from the green chlorophyte Chlamydomonas reinhardtii is an oligomer and induces biofilm formation in E. coli. FEMS Letters 339: 39–47.
  • Rakesh C. Chandarana, Vikrant, Ashok K. Varma, Anil Saran, Evans Coutinho, Jacinta S. D'Souza, (2013) Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP) 3Biotech 4: 501-506.
  • Motiwalla, M. J., Priyanka P. Punyarthi, Mansi K. Mehta, D'Souza, J. S. and Kelkar-Mane, V. (2013) Isolation and characterization of poly-capro-lactone degrading strain of Bacillus pumilus from the rhizosphere of the mangrove Sessuvium portulacastrum. J of Environmental Biotechnology, 34: 43-49.
  • Suruchi Jamkhedkar, Jyotsna Dongerdive, Kavita Jain, Siby Abraham and Jacinta S. D'Souza, (2013) Arrangement of flagella on cells: two flagella clusters emerge. Advances in Bioscience and Biotechnology, 4: 93-102
  • Rakesh C. Chandarana, Vikrant, Ashok K. Varma, Anil Saran, Evans Coutinho, Jacinta S. D'Souza, (2013) Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP) 3 Biotech DOI 10.1007/s13205-013-0181-x
  • J. S. D’Souza, J. A. Dharmadhikari, A. K. Dharmadhikari, B. J. Rao, and D. Mathur, (2011) Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: Strand breakages induced by in situ electrons and radicals. Physics Review Letters 106: 118101. Comment in Nature, India; Laser tells tale of DNA injury, doi:10.1038/nindia.2011.50; Published online 18 April 2011 (http://www.nature.com/nindia/2011/110418/full/nindia.2011.50.html)
  • Jacinta S. D'Souza, Mohanram Gudipati, Jayashree A. Dharmadhikari, Aditya K. Dharmadhikari, *Abhishek Kashyap, *Manaswini Aiyer, Usha Rao, Deepak Mathur and Basuthkar Jagadeeshwar Rao, (2009) Flagella-generated forces reveal gear-type motor in single cells of the green alga, Chlamydomonas reinhardtii. (2009) Biochem. Biophys. Res. Comm. 380: 266–270 (*Equal contribution).

Articles as Invited Book Chapters and Magazines

  • Jacinta S. D’Souza*, (2020) The 2020 Pandemic of COVID-19. Spinco Biotech Cutting Edge Volume 9(12): 16-20. L05
  • Jacinta S. D’Souza*, Ciliary Dysfunction: from relative obscurity to a formidable position. (2019) Spinco Biotech Cutting Edge (100th Edition) Volume 9(4): 64-65. L04
  • L. Sirisha, Siddhesh Ghag and Jacinta S. D’Souza* (2019) Lignin: Understanding and exploring its potential for Biofuel production. Handbook of Biotechnology for Renewable Fuels: Advanced Bioprocessing for Alternative Fuels, Biobased Chemicals, and Bioproducts. Technologies and Approaches for Scale-Up and Commercialization, Woodhead Publishing Series in Energy, Chapter 4: Pages 165-186.
  • Siddhesh B. Ghag, V. L. Sirisha and Jacinta S. D’Souza* (2019) Metabolic engineering and genetic manipulation of novel biomass species for biofuel productions. Handbook of Biotechnology for Renewable Fuels: Advanced Bioprocessing for Alternative Fuels, Biobased Chemicals, and Bioproducts. Technologies and Approaches for Scale-Up and Commercialization, Woodhead Publishing Series in Energy, Chapter 2: Pages 13-34.
  • Vavilala, S.L., Ghag, S.B. and D'Souza, J.S.*, (2018) Book review: Algal Green Chemistry Recent Progress in Biotechnology (By Rajesh Prasad Rastogi, Datta Madamwar, Ashok Pandey (2017) Elsevier, 330 pages, ISBN: 978-0-444-64041-3). Frontiers in Bioengineering and Biotechnology, 6, p.96.
  • Parte, S., Sirisha, V.L. and D’Souza, J.S.*, (2017) Biotechnological applications of marine enzymes from algae, bacteria, fungi, and sponges. In Advances in food and nutrition research. Academic Press. Vol. 80, pp. 75-106
  • L. Sirisha and J. S. D'Souza*, (2016) Polysaccharide-Based Nanoparticles as Drug Delivery Systems. Book Chapter In: Kim S-K (Ed.) Marine Omics: Principles and Applications" pp 641-682. CRC Press, USA.
  • L. Sirisha and J. S. D’Souza* (2015) Algal polysaccharides and their biological applications. Invited chapter for the book titled, ‘Marine Algae Extracts: Processes, Products, and Applications’, and chapter titled, ‘Algal Polysaccharides and Their Biological Applications’, First Edition. Edited by Se-Kwon Kim and Katarzyna Chojnacka. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2015 by Wiley-VCH Verlag GmbH & Co. KGaA. Chapter 26, pages: 411-453.
  • Rakesh Chandarana, JS D’Souza and Evans Coutinho (2012) Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Chapter in Encyclopedia of Signaling Molecules. Sangdun Choi (eds.) Springer-Verlag, New York. G: pp 773-779.
  • JS D’Souza, VG Rao and DK Khona (2012) Biosimilars: twins, but not the clones. CuttingEdge (a monthly magazine published under the auspices of Spinco Biotech), February issue, pages 25-29.
  • Jacinta S. D’Souza and Meenakshi Munshi, (2009) India’s first Research Centre for Energy Biosciences. Biotech News IV (3): 14.
Address

UM-DAE Centre for Excellence in Basic Sciences
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