Education

• PhD (Chemistry), Indian Institute of Technology Bombay, Mumbai (2012)
• MSc (Biotechnology), Jawaharlal Nehru University, New Delhi (2008)

Positions

• Reader at UM DAE Centre for Excellence in Basic Sciences (July 2022 onwards).
• Assistant Professor : UM- DAE Centre for Excellence in Basic Sciences (Jan 2016- June 2022).
• Research Associate: UM- DAE Centre for Excellence in Basic Sciences (January 2013-December 2015).
• Research Associate: Department of Chemistry, IIT Bombay (October 2012-December 2012).

Research

• Inhibition of protein fibrillation/aggregation by natural and synthetic products as potential inhibitors of aggregation-related diseases.
• Biophysical investigation of biologically important systems: drug-protein and Protein-solvent Interactions.

Selected Publications

• “Understanding the partitioning of polyamines in micelles and delivery to the carrier protein: Thermodynamic approach.” Tinku, Anitadevi K. Prajapati, Sinjan Choudhary, Journal of Molecular Liquids 346 (2022) 118303.
  
• “Targeting disorders in unstructured and structured proteins in various diseases.” Sinjan Choudhary*, Manu Lopus, Ramakrishna V. Hosur, Biophysical Chemistry, 281 (2022) 106742.
• “A thermodynamic approach to understand the partitioning of tetracycline family antibiotics in individual and mixed micellar systems.” Tinku, Sinjan Choudhary, Journal of Chemical Thermodynamics 165 (2022) 106664.
• “Functional foods and bioactive compounds in the management of neurodegenerative diseases: Editorial.” Sinjan Choudhary, International Journal of Food Science and Technology 57 (3) (2022) 1440-1441.
• “Mechanistic insights into chalcone butein-induced inhibition of α-synuclein fibrillation: Biophysical and insilico approach.” Tinku, H. Paithankar, Ankita R. Rane, Ramakrishna V. Hosur, Sinjan Choudhary* Journal of Molecular Liquids (2021) 334, 116105.
  
• “Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions.” Ankita R. Rane, Harshad Paithankar, Ramakrishna V. Hosur, Sinjan Choudhary, International Journal of Biological Macromolecules (2021) 182, 1278-1291.
• “Triphala polyphenols-functionalized gold nanoparticles impair cancer cell survival through induction of tubulin dysfunction.” J. Grace Nirmala, Kavitha Rachineni, Sinjan Choudhary, Ramakrishna V. Hosur, Manu Lopus, Journal of Drug Delivery Science and Technology 61, 2021, 102167.
• “Natural compound safranal driven inhibition and dis-aggregation of α-Synuclein fibrils.” Shreyada S. Save, Kavitha Rachineni, Ramakrishna V. Hosur, Sinjan Choudhary, International Journal of Biological Macromolecules (2019) 141, 585-595.
• “Deciphering the anti-Parkinson’s activity of sulfated polysaccharides from Chlamydomonas reindertaii on the α-synuclein mutants A30P, A53T, E46K, E57K and E35K.”Gitanjali P. Panigrahi, Ankita R. Rane, Sirisha L Vavilala, Sinjan Choudhary, Journal of Biochemistry (2019) 166(6), 463-474.
• “Triphala inhibits alpha-synuclein fibrillization and their interaction study by NMR provides insights into the self-association of the protein.” Mandar Bopardikar, Anusri Bhattacharya,  Veera Mohan Kakita, Kavitha Rachineni, Lalit Borde, Sinjan Choudhary, Sri Rama Koti Ainavarapu,  Ramakrishna V. Hosur, RSC Advances (2019) 9, 28470-28477.
• “Elucidation of energetics and mode of recognition of green tea polyphenols by human serum albumin.” Shreyada N. Save, Sinjan Choudhary, Journal of Molecular Liquids 265 (2018) 807–817. 
• “Unravelling the inhibitory activity of Chlamydomonas reinhardtii sulfated polysaccharides against α-Synuclein fibrillation.” Sinjan Choudhary*, Shreyada N Save, Vavilala L Sirisha*, Scientific Reports (2018) 8: 5692. 
• “Effects of antioxidants melatonin and glutathione on human serum albumin aggregation: biophysical studies.” Vikas Kumar, Ramakrishna V. Hosur and Sinjan Choudhary, SMC Bulletin 9 (1) 2018, 22-28. [ISSN 2394-5087]
• “Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics” Sanith Cheriyamundath, Tejashree Mahaddalkar, Shreyada N Save, Sinjan Choudhary, Ramakrishna V Hosur, Manu Lopus, Biomed Pharmacother. 98. 2018, 76-81.
• “Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules.” Sanith Cheriyamundath, Sinjan Choudhary, and Manu Lopus, Phytotherapy Research 32 (2018) 170-173. 
• “Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol” Madhura Pradhan, Charu Suri, Sinjan Choudhary, Pradeep Kumar Naik, Manu Lopus. J. biomol. Struct.  Dyn. 36(1) (2018) 195-208.
• “Effects of triphala and guggul aqueous extracts on inhibition of protein fibrillation and dissolution of preformed fibrils” Shreyada N Save, Sinjan Choudhary. RSC Adv., 2017, 7, 20460-20468.
• Elucidation of the tubulin-targeted mechanism of action of 9-(3-pyridyl) noscapine. Swagat Pradhan, Tejashree Mahaddalkar, Sinjan Choudhary, Naresh Kumar Manchukonda, Praveen Reddy Nagireddy, Srinivas Kantevari, Manu Lopus (2017) Curr Top Med Chem 17(22) ( 2017) 2569-2574.
• “Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations” Sinjan Choudhary, Shreyada N Save, Nand Kishore, Ramakrishna V. Hosur. PlosOne (2016) 11(11):e0166487.
• “Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations” Tejashree Mahaddalkar, Pradeep Kumar Naik, Sinjan Choudhary, Naresh Manchukonda, Srinivas Kantevari, Manu Lopus. J. biomol. Struct.  Dyn. (2016) 1-10. 
• “Rational Drug Design and Future Directions: Thermodynamic Perspective” Eva Judy, Sinjan Choudhary, Nand Kishore. Austin Biomol. Open Access. 1 (2016) 1003.
• “Subtle Alterations in Microtubule Assembly Dynamics by Br-TMB-Noscapine Strongly Suppress Triple-Negative Breast Cancer Cell Viability Without Mitotic Arrest”  Tejashree Mahaddalkar, Naresh Manchukonda, Sinjan Choudhary, Sanith Cheriyamundath, Neha Mohanpuria, Srinivas Kantevari, Manu Lopus, Chemistry Select 1 (2016) 4313 – 4319.
• “Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum” Anu A Thoppil, Sinjan Choudhary, Nand Kishore, Biochimica et Biophysica Acta 1860 (2016) 917–929.
• “Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights”, Sinjan Choudhary, Nand Kishore, Ramakrishna V. Hosur, Scientific Reports (2016) 5:17599 | DOI: 10.1038/srep17599.
• “Understanding thermodynamics of drug partitioning in micelles and delivery to proteins: Studies with naproxen, diclofenac sodium, tetradecyltrimethylammonium bromide, and bovine serum albumin” Paurnima Talele, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodynamics 92 (2016) 182–190.
• “Thermodynamic insights into drug-surfactant interactions: study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry” Sinjan Choudhary, Paurnima Talele, Nand Kishore, Colloids Surf B Biointerfaces 132 (2015) 313-321
• “Ribosomal Protein P2 from apicomplexan parasite, Toxoplasma gondii is intrinsically a molten globule” Pushpa Mishra, Sinjan Choudhary, Ramakrishna V. Hosur, Biophysical Chem. 200-201 (2015) 27-33.
• “Molten globule nature of Plasmodium falciparum P2 homo-tetramer” Pushpa Mishra, Sinjan Choudhary, Sujoy Mukherjee, Disha Sengupta, Shobhona Sharma, R.V. Hosur, Biochemistry and Biophysics Reports1 (2015) 97-107.
• “Addressing mechanism of fibriliization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach. Sinjan Choudhary, Nand Kishore, PLOS ONE (2014) 9(8): e104600. doi:10.1371/journal.pone.0104600.
• “Drug-protein interactions in micellar media: Thermodynamic aspects”, Sinjan Choudhary, Nand Kishore, J. Coll. Interface Sci. 413 (2014) 118-126.
• “Effects of Hesperidin, a Flavanone Glycoside Interaction on the Conformation, Stability and Aggregation of Lysozyme: Multispectroscopic and Molecular Dynamic Simulation Studies”, Aditi Ratnaparkhi, Shivani A Mutthu, Sonali M Shiriskar, Raghuvir R S Pissurlenkar, Sinjan Choudhary, Basir Ahmad, J. biomol. Struct.  Dyn.33 (2014) 1866-1879.
• “Binding thermodynamics of the recognition of the antibiotic drug oxytetracycline with bovine serum albumin” Neelam Keswani, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 58 (2013) 196-205.
• “Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin”, Sinjan Choudhary, Nand Kishore, Chem. Biol. Drug Des. 80 (2012) 693-705.
• “Physico-chemical insights into the Binding of Diclofenac Sodium and Cefotaxime Sodium to Serum Albumin : Calorimetry and Spectroscopy”, Ruchika Sharma, Sinjan Choudhary, Nand Kishore, Eur. J. Pharm. Sci. 46 (2012) 435-445.
• “Interactions of some short peptides with the osmolyte trimethylamine N-oxide in aqueous solution: physico-chemical insights” Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 52 (2012) 36-42.
• “Thermodynamics of the interactions of a homologous series of some amino acids with trimethylamine N-oxide: Volumetric, compressibility and calorimetric studies”, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 43 (2011) 1541-1551.
• “Interaction of weakly bound antibiotics, neomycin and lincomycin with serum albumin : Biophysical approach”, Neelam Keswani, Sinjan Choudhary, Nand Kishore, J. Biochem. 148 (2010) 71-84.