Sinjan Choudhary

Assistant Professor

Education

  • PhD (Chemistry), Indian Institute of Technology Bombay, Mumbai (2012)
  • MSc (Biotechnology), Jawaharlal Nehru University, New Delhi (2008)

Positions

  • Assistant Professor : UM- DAE Centre for Excellence in Basic Sciences (January 2016 onwards)
  • Research Associate: UM- DAE Centre for Excellence in Basic Sciences (January 2013-December 2015)
  • Research Associate: Department of Chemistry, IIT Bombay (October 2012-December 2012)

Research

  • Inhibition of protein fibrillation/aggregation by natural and synthetic products as potential inhibitors of aggregation-related diseases.
  • Biophysical investigation of biologically important systems: drug-protein and Protein-solvent Interactions.

Selected Publications

  • “Elucidation of energetics and mode of recognition of green tea polyphenols by human serum albumin.” Shreyada N. Save, Sinjan Choudhary, Journal of Molecular Liquids 265 (2018) 807–817. 
  • “Unravelling the inhibitory activity of Chlamydomonas reinhardtii sulfated polysaccharides against α-Synuclein fibrillation.” Sinjan Choudhary*, Shreyada N Save, Vavilala L Sirisha*, Scientific Reports (2018) 8: 5692. 
  • “Effects of antioxidants melatonin and glutathione on human serum albumin aggregation: biophysical studies.” Vikas Kumar, Ramakrishna V. Hosur and Sinjan Choudhary, SMC Bulletin 9 (1) 2018, 22-28. [ISSN 2394-5087]
  • “Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics” Sanith Cheriyamundath, Tejashree Mahaddalkar, Shreyada N Save, Sinjan Choudhary, Ramakrishna V Hosur, Manu Lopus, Biomed Pharmacother. 98. 2018, 76-81.
  • “Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules.” Sanith Cheriyamundath, Sinjan Choudhary, and Manu Lopus, Phytotherapy Research 32 (2018) 170-173. 
  • “Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol” Madhura Pradhan, Charu Suri, Sinjan Choudhary, Pradeep Kumar Naik, Manu Lopus. J. biomol. Struct.  Dyn. 36(1) (2018) 195-208.
  • “Effects of triphala and guggul aqueous extracts on inhibition of protein fibrillation and dissolution of preformed fibrils” Shreyada N Save, Sinjan Choudhary. RSC Adv., 2017, 7, 20460-20468.
  • Elucidation of the tubulin-targeted mechanism of action of 9-(3-pyridyl) noscapine. Swagat Pradhan, Tejashree Mahaddalkar, Sinjan Choudhary, Naresh Kumar Manchukonda, Praveen Reddy Nagireddy, Srinivas Kantevari, Manu Lopus (2017) Curr Top Med Chem 17(22) ( 2017) 2569-2574.
  • “Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations” Sinjan Choudhary, Shreyada N Save, Nand Kishore, Ramakrishna V. Hosur. PlosOne (2016) 11(11):e0166487.
  • “Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations” Tejashree Mahaddalkar, Pradeep Kumar Naik, Sinjan Choudhary, Naresh Manchukonda, Srinivas Kantevari, Manu Lopus. J. biomol. Struct.  Dyn. (2016) 1-10. 
  • “Rational Drug Design and Future Directions: Thermodynamic Perspective” Eva Judy, Sinjan Choudhary, Nand Kishore. Austin Biomol. Open Access. 1 (2016) 1003.
  • “Subtle Alterations in Microtubule Assembly Dynamics by Br-TMB-Noscapine Strongly Suppress Triple-Negative Breast Cancer Cell Viability Without Mitotic Arrest”  Tejashree Mahaddalkar, Naresh Manchukonda, Sinjan Choudhary, Sanith Cheriyamundath, Neha Mohanpuria, Srinivas Kantevari, Manu Lopus, Chemistry Select 1 (2016) 4313 – 4319.
  • “Competitive binding of anticancer drugs 5-fluorouracil and cyclophosphamide with serum” Anu A Thoppil, Sinjan Choudhary, Nand Kishore, Biochimica et Biophysica Acta 1860 (2016) 917–929.
  • “Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights”, Sinjan Choudhary, Nand Kishore, Ramakrishna V. Hosur, Scientific Reports (2016) 5:17599 | DOI: 10.1038/srep17599.
  • “Understanding thermodynamics of drug partitioning in micelles and delivery to proteins: Studies with naproxen, diclofenac sodium, tetradecyltrimethylammonium bromide, and bovine serum albumin” Paurnima Talele, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodynamics 92 (2016) 182–190.
  • “Thermodynamic insights into drug-surfactant interactions: study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry” Sinjan Choudhary, Paurnima Talele, Nand Kishore, Colloids Surf B Biointerfaces 132 (2015) 313-321
  • “Ribosomal Protein P2 from apicomplexan parasite, Toxoplasma gondii is intrinsically a molten globule” Pushpa Mishra, Sinjan Choudhary, Ramakrishna V. Hosur, Biophysical Chem. 200-201 (2015) 27-33.
  • “Molten globule nature of Plasmodium falciparum P2 homo-tetramer” Pushpa Mishra, Sinjan Choudhary, Sujoy Mukherjee, Disha Sengupta, Shobhona Sharma, R.V. Hosur, Biochemistry and Biophysics Reports1 (2015) 97-107.
  • “Addressing mechanism of fibriliization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach. Sinjan Choudhary, Nand Kishore, PLOS ONE (2014) 9(8): e104600. doi:10.1371/journal.pone.0104600.
  • “Drug-protein interactions in micellar media: Thermodynamic aspects”, Sinjan Choudhary, Nand Kishore, J. Coll. Interface Sci. 413 (2014) 118-126.
  • “Effects of Hesperidin, a Flavanone Glycoside Interaction on the Conformation, Stability and Aggregation of Lysozyme: Multispectroscopic and Molecular Dynamic Simulation Studies”, Aditi Ratnaparkhi, Shivani A Mutthu, Sonali M Shiriskar, Raghuvir R S Pissurlenkar, Sinjan Choudhary, Basir Ahmad, J. biomol. Struct.  Dyn.33 (2014) 1866-1879.
  • “Binding thermodynamics of the recognition of the antibiotic drug oxytetracycline with bovine serum albumin” Neelam Keswani, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 58 (2013) 196-205.
  • “Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin”, Sinjan Choudhary, Nand Kishore, Chem. Biol. Drug Des. 80 (2012) 693-705.
  • “Physico-chemical insights into the Binding of Diclofenac Sodium and Cefotaxime Sodium to Serum Albumin : Calorimetry and Spectroscopy”, Ruchika Sharma, Sinjan Choudhary, Nand Kishore, Eur. J. Pharm. Sci. 46 (2012) 435-445.
  • “Interactions of some short peptides with the osmolyte trimethylamine N-oxide in aqueous solution: physico-chemical insights” Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 52 (2012) 36-42.
  • “Thermodynamics of the interactions of a homologous series of some amino acids with trimethylamine N-oxide: Volumetric, compressibility and calorimetric studies”, Sinjan Choudhary, Nand Kishore, J. Chem. Thermodyn. 43 (2011) 1541-1551.
  • “Interaction of weakly bound antibiotics, neomycin and lincomycin with serum albumin : Biophysical approach”, Neelam Keswani, Sinjan Choudhary, Nand Kishore, J. Biochem. 148 (2010) 71-84.
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CEBS was set up by the Department of Atomic Energy and the University of Mumbai in 2007. CEBS offers a 5 year integrated MSc program in Basic Sciences, with undergraduate teaching embedded in a postgraduate and research environment, for students who have completed 10+2 schooling or its equivalent.

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